Table_1_Minimal change disease associated with thyroid cancer: a case report.DOCX

A patient complaining of edema of the face and lower extremities was admitted to the nephrology department for nephrotic syndrome. Renal biopsy revealed findings of minimal change disease (MCD). Thyroid ultrasound showed a hypoechoic 16 × 13 mm nodule in the right lobe, suspicious of malignancy. Later, total thyroidectomy confirmed the diagnosis of papillary thyroid carcinoma (PTC). After surgery, MCD remitted rapidly and completely, strongly suggesting the diagnosis of MCD secondary to PTC. We report here the first adult case of the paraneoplastic finding of MCD secondary to PTC. Additionally, we discuss the possible role of the BRAF gene in the pathophysiology of PTC-associated MCD in this case and highlight the importance of tumor screening.

一位患者因面部及下肢水肿症状入院至肾病科，诊断为肾病综合征。肾活检结果显示为微小病变病（MCD）。甲状腺超声检查发现右叶存在一个16×13毫米的低回声结节，疑似恶性。随后，全甲状腺切除术确诊为乳头状甲状腺癌（PTC）。术后，MCD迅速且完全缓解，强烈提示MCD为PTC继发。本研究报告了首例PTC继发MCD的副肿瘤综合征成人病例。此外，我们讨论了在本例中BRAF基因在PTC相关MCD的病理生理学中的可能作用，并强调了肿瘤筛查的重要性。