Dihydrofolate reductase metabolic activity controls neurogenic transitions in the developing human and mouse neocortex [RNA-seq]
收藏Alliance of Genome Resources2026-08-01 收录
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To identify how DHFR deficiency affects neurogenesis by modulating neocortical gene expression at E12.5. RNA-seq analysis of E12.5 neocortical tissues isolated from WT and DHFR+/delta mice.
本研究旨在探究二氢叶酸还原酶（DHFR）缺陷如何通过调控胚胎第12.5天（embryonic day 12.5，E12.5）的新皮层基因表达，进而影响神经发生。本数据集对分离自野生型（Wild Type，WT）和DHFR+/delta小鼠的E12.5新皮层组织进行了RNA测序（RNA Sequencing，RNA-seq）分析。
