Ru(II)-Catalyzed C–H Aminocarbonylation of N‑(Hetero)aryl-7-azaindoles with Isocyanates

The ruthenium­(II)-catalyzed C–H aminocarbonylation of N-(hetero)­aryl-7-azaindoles with isocyanates is described. The excellent site selectivity at the ortho-position within the N-(hetero)­aryl ring was observed to provide ortho-amidated N-(hetero)­aryl-7-azaindoles under the mild reaction conditions. The resulting 7-azaindole derivatives can be readily transformed into 7-azaindoles containing carboxylic acid and alkyl amine functional groups.