Photoactivatable senolysis with single-cell resolution reverses aging

Emerging evidence supports the use of pharmaceutical interventions to target senescent cells (SnCs) and induce their death (senolysis) to extend a healthy lifespan. The challenge then becomes how to achieve precise, broad-spectrum and tractable senolysis. To this end, we have designed a novel senotherapeutic agent with an unprecedented integrated strategy Overall design: Examination of Young control, Aged control and KSL0608-Se + irradiation groups in livers of mice by RNA-seq, five replicates