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Role of Yng2 PHD and CHD-containing Eaf3 subunits of NuA4 on genome wide histone H4K8 acetylation, NuA4 localization and Pol II distribution

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The NuA4 acetyltransferase complex contains two reader modules, an H3K4me3-specific PHD domain within the Yng2 subunit and H3K36me2/3-specific chromodomain in the Eaf3 subunit

NuA4乙酰转移酶复合物(NuA4 acetyltransferase complex)包含两个读取模块(reader modules):一个是位于Yng2亚基内、特异性识别H3K4me3的PHD结构域(PHD domain),另一个是存在于Eaf3亚基中、特异性识别H3K36me2/3的染色质结构域(chromodomain)

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