Danlu Tongdu Tablets: Safety evaluation and mechanism of hepatotoxicity in Sprague-Dawley rats

Based on the acute and chronic toxicity study, we further focused on the impact of Danlu Tongdu (DLTD) on the liver. At the end of 26 weeks of administration, 4 male rats were selected from the control group and the high-dose group respectively for transcriptome analysis. The selection criteria were random selection from the control group, the four rats selected from the high-dose. group showed pathological changes in the liver. Overall design: Rats were randomized into 2 groups. Rats in the control group (4 rats) were treated with ultrapure water; rats in the high-dose group (4 rats) were treated with 6.67 g/kg Danlu Tongdu.