Demographic, clinical and CSF data of analyzed patients.

1 data are shown as median (range), p-value: groups were compared using 2 Qui-Square test or 3 Kruskal-Wallis test and Dunn's multiple comparison post-hoc test, # statistically significant different from OND control group.Abbreviations: n = number of patients, y = years, EDSS = expanded disability status score, acute relapse = number of patients with an acute relapse, MRI Gd+ lesions = presence of gadolinium-enhancing lesions on T1-weighted MRI (neg = negative, pos = positive), ≥9 T2 MRI lesions = ≥9 lesions on T2-weighted MRI, OCB = oligoclonal bands, Q-Alb = albumin quotient, MMP = matrix metalloproteinase, ratio = CSF∶serum ratio, ns = statistically not significant.