Synergistic and Selective Copper/ppm Pd-Catalyzed Suzuki–Miyaura Couplings: In Water, Mild Conditions, with Recycling

Copper-catalyzed Suzuki–Miyaura couplings can be carried out exclusively on aryl iodides under very mild conditions, which is made possible by synergistic effects due to the presence of ppm levels of palladium as cocatalyst. The coupling requires a hemilabile P(O)-N ligand, together with the benefits of micellar catalysis using water as the recyclable reaction medium.