Enzymatic reactions included in the model a.

aFrom [8].b,cThe enzyme activities in the model were divided into 3 groups: activities of 8 enzymes in purine salvage pathway (b), the activity of the Na+/K+ pump (c), and the remaining other enzymatic or binding activities [9].d,e,fAbbreviations used in this table are as follows: GLC, glucose; G6P, glucose 6-phosphate; F6P, fructose 6-phosphate; F1,6-BP, fructose 1,6-bisphosphate; DHAP, dihydroxyacetone phosphate; GA3P, glyceraldehyde 3-phosphate; 1,3-BPG, 1,3-bisphosphoglycerate; 2,3-BPG, 2,3-bisphosphoglycerate, 3PG, 3-phosphoglycerate; 2PG, 2-phosphoglycerate; PEP, phosphoenolpyruvate; PYR, pyruvate; LAC, lactate; GL6P, gluconolactone 6-phosphate; GO6P, gluconate 6-phosphate; RU5P, ribulose 5-phosphate; X5P, xylulose 5-phosphate; E4P, erythrose 4-phosphate; S7P, sedoheptulose 7-phosphate; R5P, ribose 5-phosphate; PRPP, 5-phosphoribosyl 1-phosphate; ADE, adenine; IMP, inosine monophosphate; R1P, ribose 1-phosphate; INO, inosine; ADO, adenosine; HX, hypoxanthine; AMP, adenosine monophosphate; ADP, adenosine diphosphate; ATP, adenosine triphosphate; NADP, nicotinamide adenine dinucleotide phosphate; NADPH, nicotinamide adenine dinucleotide phosphate (reduced); NAD, nicotinamide adenine dinucleotide; NADH, nicotinamide adenine dinucleotide (reduced); Ki, potassium ion; Nai, Sodium ion; Pi, inorganic phosphate; L_GC, l-glutamyl cysteine; GSH, glutathione (reduced); GSSG, glutathione (oxidized).