Information S1 - AKAP13 Rho-GEF and PKD-Binding Domain Deficient Mice Develop Normally but Have an Abnormal Response to β-Adrenergic-Induced Cardiac Hypertrophy

Analysis of cardiac and developmental expression and gene-trap events for the AKAP family. A literature review was conducted to identify AKAPs expressed in cardiac tissue and that have cardiac phenotypes in cell culture or animals. The type of cardiac phenotype is indicated: Hyper = hypertrophy, Ca2+ = calcium regulation, K+ = potassium regulation, Dev = development. Publicly available microarray data sets were mined to determine the expression of AKAPs during mouse development and embryonic stem (ES) cell differentiation. Absolute fold changes are reported when greater than 1.8, and expressed, but unchanged, genes are marked as present (P). The number of uniquely trapped exons for each AKAP gene is indicated. (DOC)