Probing tumorigenic potentials of the genetic interactions reconstituted in murine fallopian tube organoids. Probing tumorigenic potentials of the genetic interactions reconstituted in murine fallopian tube organoids

Despite histological diversity in the subcutaneous nodules and tumors, the derived tumor-derived organoids stereotypically exhibited cystic featuresTo clarify molecular differences among the p53-null falopian tube-derived tumors driven by KrasG12D, Pik3caH1047R, and Apc580D, the transcriptome across tumor-derived organoidss, originating organoids before inoculation, p53-null organoids without driver mutations, and organoids without recombination as a reference were compared. Overall design: The Trp53flox/flox mice-derived FT organoids transduced with the control vector pLKO.1 served as a reference for gene expression. Three pairs of organoids before injection and derived from tumors were analyzed.