Effect of 52 weeks of chronic exposure to TCDD AND PCB126 on hepatic gene expression

This study investigates the effects of the aryl hydrocarbon receptor (AhR) ligands TCDD and PCB126 on hepatic gene expression in female sprague dawley rats. Rats were treated with toxicological equivalent doses of TCDD (100ng/kg/day) (Toxic equivalence factor (TEF) = 1.0), PCB126 (30ng, 300ng or 1000ng/kg/day) (TEF = 0.1) or a vehicle control of corn oil:acetone (99:1) 5 days a week for 52 weeks.本研究探讨了芳香烃受体（aryl hydrocarbon receptor, AhR）配体TCDD与PCB126对雌性斯普拉格-道利大鼠（Sprague Dawley rats）肝脏基因表达的影响。实验中，大鼠以毒性当量剂量分别接受TCDD（100ng/kg/天，毒性当量因子（Toxic Equivalence Factor, TEF）=1.0）、PCB126（30ng、300ng或1000ng/kg/天，TEF=0.1）处理，或以玉米油:丙酮（99:1）作为溶剂对照，每周给药5天，持续52周。