Investigating the optimal scheduling of chemotherapy in patients with colorectal and liver cancer

See https://www.cancerresearchuk.org/about-cancer/find-a-clinical-trial/a-study-looking-chemotherapy-surgery-people-bowel-cancer-that-spread-liver-epoc-b#undefined
Background and study aims
Colorectal cancer is cancer that begins in the large bowel. When a cancer spreads to the liver, the tumours that form are called liver metastases. Operable/resectable liver metastases are metastases that can be removed with surgery. The aim of this study is to compare two treatment strategies for patients who have operable liver metastases from colorectal cancer. We will compare the side effects following surgery and chemotherapy, quality of life and survival for the two strategies. This will tell us whether it is possible to conduct a larger study to determine which strategy is better for patients.
Who can participate?
Patients aged 18 or over with colorectal cancer and operable liver metastases.
What does the study involve?
Patients are randomly allocated to one of two groups. Patients in one group undergo surgery to remove their liver metastases and are then treated for 24 weeks with standard chemotherapy. Patients in the other group undergo chemotherapy treatment for 12 weeks before and 12 weeks after surgery. After completion of the study treatment both groups are followed up every 3 months for 2 years, and every 6 months thereafter for a further 3 years or until their disease progresses.