Myeloid dickkopf-1 fuels neurovascular and neuroimmune alterations in ischemic stroke. (Source data)

Myeloid dickkopf-1 fuels neurovascular and neuroimmune alterations in ischemic stroke, dataset. <br> Fig. 1 : <em>Dkk1</em> mRNA is detected at the lesion site but not in the intact tissue, and its conditional induction has limited effects in absence of injury. <br> Fig. 2 : Early DKK1 induction accelerates sensorimotor impairments and exacerbates injury. <br> Fig. 3 : Brain perfusion and revascularization are impaired following early DKK1 induction. <br> Fig. 4 : Neuroinflammation and glial scar organization are deregulated after early DKK1 induction. <br> Fig. 5 : Delayed induction of DKK1 hinders neurological recovery, promotes anxiety-like behavior and attenuates synaptic plasticity. <br> Fig. 7 : DKK1 <em>de novo</em> expression at the lesion site after stroke originates from infiltrating BMDCs. <br> Fig. 8 : Pharmacological deactivation of DKK1 promotes structural and neurological recovery. <br> Extended data fig. 1 : Early induction of DKK1 aggravates structural damage after stroke. <br> Extended data fig. 2 : DKK1 induction prior to stroke impairs neuronal differentiation and neuronal activity. <br> Extended data fig. 3 : Delayed DKK1 post-stroke induction does not affect locomotion in the open field test. <br> Extended data fig. 4 : Ischemic stroke modulates the transcriptomic profiles of the brain tissue. <br> Extended data fig. 5 : Validation of chimerism validation in chDKK1 mice. <br> Extended data fig. 6 : DKK1 subacute neutralization reduces brain damage after stroke.