National Institute on Aging (NIA) SardiNIA Study

Sardinia is the second largest island in the Mediterranean and constitutes a genetically isolated founder population. This population has aided in the identification of genes involved in several Mendelian disorders and is attractive for genetic studies due to its organization in long-established settlements that developed from an initial group of founder settlers (~1,000) thousands of years ago. The current study has recruited 6,148 Sardinians aged 14 and older, from a cluster of four towns in the Lanusei Valley in the Ogliastra region of the province of Nuoro. This sample corresponds to approximately 62% of the population eligible in the area for recruitment. Information collected during enrollment allowed the individuals to be organized into 711 complex pedigrees, each up to five generations deep, with an average kinship coefficient of 0.1628. All volunteers have been characterized for 98 quantitative traits. Traits include anthropomorphic measures, plasma and serum markers (including cholesterol and other markers of cardiovascular disease), and personality traits (using the five-factor model). The main goal of the study is to examine phenotypic similarities between relatives that yield information on the overall contributions of genes to trait variability. Data given here provide p-values for 98 traits studied in 1,412 individuals, based on genotyping with the Affymetrix 500K chip and imputed markers using the HapMap population as a reference (N=2,259,179). Sharing this genome assessment data at high level of resolution for a variety of quantitative traits will be useful for other groups to validate newly observed associations and to investigate possible pleiotropic effects. For ulterior information, and in particular for any individual genotype information, a formal request should be addressed to the Steering Committee, c/o David Schlessinger, Chief, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, 251 Bayview Blvd., Suite 100 Baltimore, MD 21224 USA and should include IRB approval of a detailed proposal, along with a signed statement guaranteeing that no attempt will be made to identify any individual participant.]]>
We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of body mass index. The sample size is 1410 (658 males and 752 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of hip (cm). The sample size is 1411 (659 males and 752 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of standing height (cm). The sample size is 1410 (659 males and 751 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of waist (cm). The sample size is 1411 (659 males and 752 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of weight (kg). The sample size is 1410 (658 males and 752 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of erythrocyte sedimentation rate (mm/h). The sample size is 1411 (658 males and 753 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of fetal hemoglobin (%). The sample size is 1400 (656 males and 744 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of glucose-6-phosphate dehydrogenase (ui/dl). The sample size is 1411 (658 males and 753 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of hemoglobin (g/dl). The sample size is 1408 (659 males and 749 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of hemoglobin a2 (%). The sample size is 1411 (658 males and 753 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of mean corpuscular hemoglobin (pg). The sample size is 1408 (659 males and 749 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of mean corpuscular volume (fl). The sample size is 1408 (659 males and 749 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of platelet count (10^3/ul). The sample size is 1406 (656 males and 750 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of red blood cells (10^6/ul). The sample size is 1406 (658 males and 748 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of serum iron (g/dl). The sample size is 1412 (659 males and 753 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of transferrin (mg/dl). The sample size is 1412 (659 males and 753 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of acceleration time. The sample size is 1386 (645 males and 741 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of cca intima media thickness. The sample size is 1395 (652 males and 743 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of diastolic blood pressure (mmhg) - average 2-3 measurements. The sample size is 1408 (656 males and 752 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of diastolic cca diameter. The sample size is 1388 (646 males and 742 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of end systolic velocity. The sample size is 1386 (644 males and 742 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of heart rate (beats per minute). The sample size is 1410 (659 males and 751 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of heartrate-corrected qt interval. The sample size is 1411 (659 males and 752 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of integral time velocity. The sample size is 1386 (645 males and 741 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of mean atrial pressure (diastolic blood pressure + (pulse pressure/3)). The sample size is 1408 (656 males and 752 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of normalized pulse wave velocity (pulse wave velocity/mean atrial pressure). The sample size is 1372 (636 males and 736 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of peak systolic velocity. The sample size is 1387 (645 males and 742 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of pr interval (msec). The sample size is 1394 (647 males and 747 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of pulsativity index. The sample size is 1386 (645 males and 741 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of pulse pressure (systolic blood pressure - diastolic blood pressure). The sample size is 1408 (656 males and 752 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of pulse wave velocity. The sample size is 1372 (636 males and 736 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of systolic blood pressure (mmhg) - average 2-3 measurements. The sample size is 1408 (656 males and 752 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of systolic cca diameter. The sample size is 1386 (644 males and 742 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of sytolic diastolic ratio. The sample size is 1385 (644 males and 741 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of vascular mass (1.06 x cca intima-media thickness x (cca intima-media thickness+diastolic cca diameter)). The sample size is 1381 (644 males and 737 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of wall lumen ratio (2 x cca intima-media thickness / diastolic cca diameter). The sample size is 1381 (644 males and 737 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of basophils (%). The sample size is 1398 (654 males and 744 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of eosinophils (%). The sample size is 1398 (654 males and 744 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of lymphocytes (%). The sample size is 1397 (654 males and 743 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of monocytes (%). The sample size is 1397 (653 males and 744 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of neutrophils (%). The sample size is 1396 (653 males and 743 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of white blood cell count (10^3/ul). The sample size is 1407 (659 males and 748 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of c-reactive protein (mg/dl). The sample size is 1404 (655 males and 749 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of blood urea nitrogen (mg/dl). The sample size is 1409 (657 males and 752 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of serum creatinine (mg/dl). The sample size is 1409 (657 males and 752 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of uric acid (mg/dl). The sample size is 1412 (659 males and 753 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of potassium (meq/l). The sample size is 1412 (659 males and 753 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of sodium (meq/l). The sample size is 1410 (658 males and 752 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of hdl cholesterol (mg/dl). The sample size is 1412 (659 males and 753 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of ldl cholesterol (friedwald formula). The sample size is 1409 (656 males and 753 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of total cholesterol (mg/dl). The sample size is 1412 (659 males and 753 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of triglycerides (mg/dl). The sample size is 1409 (656 males and 753 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of alanine aminotransferase (u/l). The sample size is 1410 (657 males and 753 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of aspartate aminotransferase (u/l). The sample size is 1409 (656 males and 753 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of fibrinogen (mg/dl). The sample size is 1411 (658 males and 753 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of fractinated bilirubin (mg/dl). The sample size is 1408 (658 males and 750 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of gamma-glutamyltransferase (u/l). The sample size is 1409 (656 males and 753 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of total bilirubin (mg/dl). The sample size is 1410 (658 males and 752 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: achievement striving. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: actions. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: activity. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: aesthetics. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: agreeableness. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: altruism. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: angry hostility. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: anxiety. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: assertiveness. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: competence. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: compliance. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: conscientiousness. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: deliberation. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: depression. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: dutifulness. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: excitement-seeking. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: extraversion. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: fantasy. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: feelings. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: gregariousness. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: ideas. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: impulsiveness. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: modesty. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: neuroticism. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: openness. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: order. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: positive emotions. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: self-consciousness. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: self-discipline. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: straightforwardness. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: tender-mindedness. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: trust. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: values. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: vulnerability. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of trait from NEO Personality Inventory - Revised: warmth. The sample size is 1277 (583 males and 694 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of prostate-specific antigen (u/l). The sample size is 657 (657 males and 0 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of thyroid stimulating hormone (u/l). The sample size is 739 (3 males and 736 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of glycated hemoglobin(%). The sample size is 735 (372 males and 363 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of serum glucose level (mg/dl). The sample size is 1412 (659 males and 753 females) and covariates are age, age square and sex.We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, in 1500 individuals, based on genotyping with an Affymetrix 500K SNP array platform, focusing on facets of personality and cardiovascular function. The association results presented are from Sardinia genome wide association analysis of serum insulin level (u/ml). The sample size is 1369 (643 males and 726 females) and covariates are age, age square and sex.Participant ages were 14 years and older. Among the 1,412 individuals included in this project, there were 659 males and 753 females. All analyses were conducted using age, age squared and sex as covariates, and traits were transformed using quantile normalization.]]>
2001: Project started 2006: First publication in PLoS Genetics on heritability estimation of 98 quantitative traits 2007: First genome-wide association scan publication in PLoS Genetics ]]>