Clinical outcome of MCI cases by peptide pattern.

Clinical outcome of MCI cases (n = 32) followed up for a mean of 57 months. MCI cases with a positive score for the AD-pattern (n = 21) or a negative score for the AD-pattern (n = 11) according to our peptide panel. From 21 MCI patients originally identified as having a positive score for the AD pattern in CSF, only 7 patients are still clinically diagnosed with MCI, while 14 progressed into clinical AD. The other MCI group with negative score for the AD pattern showed a different outcome. Here only 2 patients progressed into AD so far, while 5 patients are still diagnosed with a stable MCI, one patient progressed into a vascular dementia (other dementia, OD), and 3 patients developed a complete remission of cognitive symptoms.