Additional file 1 of Identification and validation of core genes for type 2 diabetes mellitus by integrated analysis of single-cell and bulk RNA-sequencing

Additional file 1: Figure S1. Visualization of cells distribution in GSE81608 and GSE86469 among clusters at different resolutions through K-means clustering algorithm. A GSE81608, the resolution is 0.7 was considered as a cutoff. B GSE86469, the resolution is 0.8 was considered as a cutoff. Figure S2. Expressions of the five DEMGs in the three cell types over trajectory time. Trend in expressions of five DEMGs during differentiation of three cell types over trajectory time. Figure S3. Expression of CDKN1C and DLK1 in different cell clusters of non-diabetic and T2DM samples. A Expression of CDKN1C in different cell clusters of non-diabetic and T2DM samples. B Expression of DLK1 in different cell clusters of non-diabetic and T2DM samples. Figure S4. Expression of CDKN1C and DLK1 in the major endocrine clusters, acinar cell and ductal cell of non-diabetic and T2DM samples. A The expression level of CDKN1C and DLK1 in major pancreatic cells of non-diabetic and T2DM patients. B The t-SNE plot of CDKN1C and DLK1 expressed in endocrine cells and exocrine cells. Figure S5. Relevance analysis between DEMGs and patient age. A Relevance analysis between CDKN1C and patient age. B Relevance analysis between DLK1 and patient age.