RNA-seq analysis explored the mechanism of BHLHE22's involvement in TNBC progression

Basic helix-loop-helix family, member e22 (BHLHE22), a basic helix loop helix transcription factor family member, functions vary in different type of cancer. Currently, its function in triple-negative breast cancer (TNBC) is unclear. The mRNA-seq analysis was performed to identify potential genes for the anti-cancer role of BHLHE22., , , # RNA-seq analysis explored the mechanism of BHLHE22's involvement in TNBC progression

[https://doi.org/10.5061/dryad.xksn02vsg](https://doi.org/10.5061/dryad.xksn02vsg)

## Description of the data and file structure:

RNA gene expression profiles in MDA-MB-157 cells with or without BHLHE22 overexpression. The file contains the list of differentially expressed genes.

The inducible expression pLVX-TetOne-Puro vector was used to overexpress BHLHE22 in MDA-MB-157 cells. After cell infection, the infected cells were treated with doxycycline (dox, 1 μg/mL) to induce BHLHE22 overexpression. Then, the infected cells were underwent sequencing. The sequencing images were generated by the sequencing platform and converted into sequential data (reads) by CASAVA base recognition. The fastq file contains the sequence information of sequencing fragments and their corresponding sequencing quality information. The raw data from sequencing contained a small number of reads with sequencing connectors o...,