All-trans retinoic acid protects against transmissible gastroenteritis virus-induced intestinal injury and intestinal epithelial apoptosis in piglets through inhibition of oxidative stress and endoplasmic reticulum stress

This research found that ATRA protects gut health by suppressing TGEV-induced intestinal epithelial apoptosis, thereby inhibiting diarrhea in piglets. Its mechanism is related to the inhibition of oxidative stress-mediated P38MAPK/JNK signaling pathways and ERS-mediated PERK/ATF6-CHOP signaling pathways