Differences in vaginal microbiota, host transcriptome and proteins in women with bacterial vaginosis are associated with metronidazole treatment response. human vaginal metagenome (1632839)

This study aimed to identify features associated with bacterial vaginosis treatment response. Women with BV in Bronx, NY and Thika, Kenya received 7 days of oral metronidazole and underwent genital sampling of the vaginal microbiota on Days 0, 15 and 35. Bronx participants were more likely than Thika participants to clinically respond to metronidazole, also noted by changes in the microbiota composition and alpha diversity.