Effect of Arid1a deletion in antiviral effector CD8+ T cells. [RNA-seq]

To investigate the roll of ARID1A in the regulation of effector CD8+ T cell responses, we crossed GzmB-Cre P14 Thy1.1 mice with Arid1a-fl/fl mice to generate Arid1a Het and KO mice. We then performed gene expression profiling analysis of WT, Het, and KO cells in vivo at d3, d5, and d8 post-LCMV Armstrong infection. Overall design: RNA-seq gene expression profiling analysis for WT, Arid1a Het, and Arid1a KO P14 CD8+ T cells at d3 (total cells) and d8 (TE, EEC, and MP cell subsets) following LCMV Armstrong infection.