热休克因子HSF1/HSF2与HSE复合物结构

数据集以热休克因子HSF1/HSF2为研究对象，分别解析了HSF1、HSF2的DBD结构域二聚体、三聚体与热休克原件HSE复合物的晶体结构，对HSF结合与识别HSE的方式进行了分析，帮助我们更加深入地了解HSF发挥功能的机理，为探究HSF在不同生命过程如氧化应激反应中的作用机制奠定了基础。

This dataset focuses on heat shock factors HSF1 and HSF2. It respectively solved the crystal structures of the DNA-binding domain (DBD) dimers and trimers of HSF1 and HSF2, as well as the complexes of these oligomers with heat shock element (HSE). Subsequently, it analyzed the binding and recognition modes of HSE by HSFs, which deepens our understanding of the functional mechanisms of HSFs and lays a solid foundation for investigating the regulatory roles and underlying mechanisms of HSFs in diverse biological processes including oxidative stress response.

搜集汇总

背景与挑战

背景概述

该数据集解析了热休克因子HSF1和HSF2的DBD结构域二聚体、三聚体与热休克原件HSE复合物的晶体结构，旨在深入理解HSF结合与识别HSE的机制，为研究HSF在氧化应激反应等生命过程中的作用提供基础。数据集包含11个文件，总数据量为14.4MB。