Supporting data for Transcutaneous Auricular Vagus Nerve Stimulation: Unveiling Its Underlying Neural Mechanisms and Potential for Alleviating Depression

Depression is a highly prevalent neuropsychiatric illness and one of the leading causes of health-related disease burden. The COVID-19 pandemic has exacerbated the detriment conditions, with an enormous upsurge in depression cases. The unsatisfactory response of depression episodes to the currently available treatments poses a major clinical and socioeconomic problem.  The complex pathophysiology of depression may involve multiple central and peripheral nervous systems, resulting in challenges in effectively treating depression. Therefore, alternative therapeutic strategies are needed to target multiple depression-related mechanisms for improving treatment efficiency.  Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel and promising non-invasive technique for treating depression. The current study investigated the antidepressant-like activities of chronic taVNS and its potential mechanisms in a model of depression.  The current dataset contains all the data related to the antidepressant activity of taVNS and its underlying mechanisms of action.

抑郁症是一种高发的神经精神疾病，也是导致健康相关疾病负担的主要原因之一。COVID-19大流行加剧了损害状况，抑郁症病例急剧上升。目前可用治疗方法对抑郁症发作的响应不尽人意，这构成了重大的临床和社会经济问题。抑郁症复杂的病理生理机制可能涉及多个中枢和外周神经系统，从而给有效治疗抑郁症带来了挑战。因此，需要探索替代的治疗策略，以针对多个与抑郁症相关的机制，从而提高治疗效果。经皮耳穴迷走神经刺激（taVNS）是一种新颖且具有潜力的非侵入性抑郁症治疗方法。本研究旨在探究慢性taVNS在抑郁症模型中的抗抑郁样作用及其潜在机制。当前数据集包含了与taVNS抗抑郁活性及其作用机制相关的所有数据。