ChIP-Seq for LXR in the mouse substantia nigra midbrain dopaminergic cell line SN4741 treated with the synthetic LXR ligand GW3965 for 1.5 hours

We investigated mechanisms by which LXRs regulate midbrain dopaminergic neuron development. Using a systems biology approach, we found that LXR interacts with ß-catenin and that LXR activation inhibits the activity of the Wnt/ß-catenin pathway Overall design: Two replicates each of input with or without GW3965, and two replicates each with LXR antibody with or without GW3965