FuzDB Database of fuzzy protein complexes

FuzDB compiles experimentally observed fuzzy protein complexes, where intrinsic disorder (ID) is maintained upon interacting with a partner (protein, nucleic acid or small molecule) and directly impacts biological function. Entries in the database have both (i) structural evidence demonstrating the structural multiplicity or dynamic disorder of the ID region(s) in the partner bound form of the protein and (ii) in vitro or in vivo biological evidence that indicates the significance of the fuzzy region(s) in the formation, function or regulation of the assembly. Unlike the other intrinsically disordered or unfolded protein databases, FuzDB focuses on ID regions within a biological context, including higher-order assemblies and presents a detailed analysis of the structural and functional data.FuzDB 收录了经实验观测得到的模糊蛋白质复合物，这类复合物在与伴侣分子（蛋白质、核酸或小分子）结合时仍保留固有无序（intrinsic disorder, ID）特性，且该特性直接影响其生物学功能。该数据库的每条条目均同时满足两项判定标准：其一，存在结构证据，可证明蛋白质在结合伴侣分子的状态下，其固有无序区域具有结构多重性或动态无序特性；其二，拥有体外（in vitro）或体内（in vivo）生物学证据，证实模糊区域在该组装体的形成、功能发挥或调控过程中发挥关键作用。与其他固有无序或解折叠蛋白质数据库不同，FuzDB聚焦于生物学场景中的固有无序区域，涵盖高阶组装体，并对相关结构与功能数据进行了详尽解析。

搜集汇总

背景与挑战

背景概述

FuzDB是一个专门收集实验观测到的模糊蛋白质复合物的数据库，这些复合物在结合伙伴后仍保持内在无序性，并直接影响生物功能。它结合结构证据与生物证据，专注于生物背景下（包括高阶组装）的内在无序区域分析，以支持对蛋白质相互作用的深入理解。