Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production

Female Wistar rats were either fed nutrient source-matched control diet (control) or a high fat diet (HFD). HFD-fed rats presented with increased ICP, which was not accompanied by altered CSF dynamics or modified choroid plexus function. HFD-induced ICP elevation in experimental rats did not originate from an increased rate of CSF secretion.将雌性Wistar大鼠分为两组，分别饲喂营养源匹配的对照饲料（对照组）或高脂饮食（high fat diet, HFD）。饲喂高脂饮食的大鼠出现颅内压（intracranial pressure, ICP）升高，但该升高并未伴随脑脊液（cerebrospinal fluid, CSF）动力学改变或脉络丛（choroid plexus）功能异常。本实验中，高脂饮食诱导的大鼠颅内压升高并非由脑脊液分泌速率增加所致。