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Expedient Enantioselective Synthesis of Cermizine D

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NIAID Data Ecosystem2026-03-09 收录
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https://figshare.com/articles/dataset/Expedient_Enantioselective_Synthesis_of_Cermizine_D/2539951
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An efficient enantioselective synthesis of cermizine D has been developed that exploits the use of a common intermediate to access over 85% of the carbon backbone. Key steps include an organocatalyzed heteroatom Michael addition, a diastereoselective alkylation with α-iodomethyl phenyl sulfide, a conjugate addition to a vinyl sulfone species, and a sulfone coupling/desulfurization sequence to join the two major subunits.
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2016-02-21
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