Deep sequencing results for viruses previously implicated in MS pathogenesis.

1Viral taxa are defined as sequences in GenBank below the level of family. This includes sequences identified as belonging to genus or species or subspecies (strain). It also includes sequences not assigned to a specific species or genus.2The MS Specimen Hit Rate is defined as the number of hits for a given taxon or species divided by the number of total non-ribosomal reads. This method is used to normalize these values between specimens. The range of hit rates among the 17 sequenced MS brain specimens is displayed.3The control specimen hit rates for each viral taxon are expressed as the mean ± SEM among the 8 control specimens.4Null hypothesis = the tested MS specimen falls within the expected distribution of control samples. Values provided are two-tailed. The minimum p-value among all 17 tested MS samples is shown.*The p-value could not be calculated because the control hit rates are not normally distributed.