Characterization of structural variants in canine carcinoma and sarcoma

Solid tumors were histopathologically categorized into carcinomas and sarcomas and analyzed based on structural variations specific to each group. To investigate this, we utilized whole genome sequencing (WGS) data from dogs with solid tumors, including carcinomas and sarcomas. Structural variations, which induce extensive base changes, significantly impact tumor development. Through our analysis, we identified 146,847 structural variations within the solid tumor data. By comparing each solid tumor group, we identified both common genes affecting tumors across groups and differential genes unique to carcinomas and sarcomas. This finding suggests that understanding the specific genetic alterations associated with each tumor type can enhance the accuracy of diagnosis, inform treatment strategies, and improve prognostic assessments.