Gene-collapsing analysis of clonal haematopoiesis in 136,401 Admixed Americans and 416,118 Europeans

We performed gene-collapsing (gene burden) analysis of germline genetic variants identified from whole-exome sequencing (WES) to identify novel inherited genetic determinants of clonal haematopoiesis (CH). Here, we provide the summary statistics from CH gene-collapsing analysis performed on Admixed Americans recruited to the Mexico City Prospective Study (MCPS), Europeans recruited to the United Kingdom Biobank (UKB), and cross-ancestry meta-analysis of Admixed Americans and Europeans. Analyses was performed with Fisher's exact test (for MCPS and UKB analysis) and Cochran–Mantel–Haenszel test (for meta-analysis).