Transcriptomic study in zebrafish larvae

Soybean meal evokes diet-induced intestinal inflammation in certain fishes. We fed zebrafish larvae with three diets- control, soybean meal and soybean meal with beta-glucan to assess the effect of the diets on larval transcriptome to gain deeper insights associated with the soybean meal-induced inflammation model. Transcriptomic analysis point to effects associated with the suppression of genes linked to visual perception, organ development, the phototransduction pathway and activation of genes linked to the steroid biosynthesis pathway. Transcriptomic data also revealed that beta-glucan can reduce soybean meal-induced alterations by reducing inflammatory cytokine signalling, inhibiting proteolysis and inducing epigenetic modifications. In conclusion, our data provide the extra-intestinal effects associated with the soybean meal-induced inflammation model.