Simultaneous patch-clamp and dense CMOS probe extracellular recordings from the same cortical neuron in anaesthetized rats

In this dataset, we recorded simultaneously from the same cortical neuron using patch-clamp and extracellular (Neuropixel, 384 channel) probes, in urethane-anaesthetized rats (no stimulus, just spontaneous activity). A total of 43 neurons were recorded from in primary motor and somatosensory cortex. 38 neurons were recorded in cell-attached mode and 5 in whole-cell. Out of the 43 neurons that we patched, 21 showed clear extracellular spike waveforms, and for 10 of these the peak-peak amplitude exceeded 50 µV. For each neuron, we provide the raw extracellular recording file (action potential band, high-pass filtered at 300 Hz) and the corresponding patch-clamp recording, as well as sync channels for the two modalities, sample number for spike peaks in the patch-clamp recording, and corresponding sample numbers in the extracellular recording. Results from the experiments and detailed information about the dataset are described in:

Recording from the same neuron with high-density CMOS probes and patch-clamp: a ground-truth dataset and an experiment in collaboration.
André Marques-Smith, Joana Pereira Neto, Gonçalo Lopes, Joana Nogueira, Lorenza Calcaterra, João Frazão, Danbee Kim, Matthew G. Phillips, George Dimitriadis, Adam Kampff. bioRxiv 370080; doi: https://doi.org/10.1101/370080