Data from: Randomized comparison of sevoflurane versus propofol-remifentanil on the cardioprotective effects in elderly patients with coronary heart disease

Background It is skeptical about cardioprotective property of sevoflurane
in patients undergoing noncardiac surgery, especially in the elderly
patients with coronary heart disease. We hypothesized that long duration
of sevoflurane inhalation in noncardiac surgery could ameliorate
myocardial damage in such patients. Methods This was a randomized,
prospective study. One hundred twenty-one elderly patients with coronary
heart disease were randomly allocated into two groups. Maintenance of
anesthesia was achieved by sevoflurane inhalation (Group S) or
propofol-remifentanil respectively (Group PR). Serum cardiac troponin I
(cTnI) and brain natriuretic peptide (BNP) were measured before anesthesia
induction (T0), 8 h (T1) and 24 h (T2) after anesthesia respectively. The
perioperative cardiac output, complications and postoperative 3-month
follow-up from end of surgery were recorded. Results Between the two
groups, there were no statistical differences in the values of cTnI and
BNP during the study. However, The area under the curve of cTnI values
over 24 h after operation was less in Group S. Group PR had lower cardiac
output and consumed more amount of phenylephrine during the study (P
< 0.05). Conclusions Compared with the group PR, sevoflurane had no
benefit in the myocardial protection for the elderly patients with CHD.
However, Sevoflurane showed advantage in maintaining hemodynamic stability
during the operative period.