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Mutant p53 alters chromatin accessibility in hematopoietic stem and progenitor cells.

NIAID Data Ecosystem2026-05-01 收录

造血干细胞表观遗传学

p53突变功能研究

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE261634 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2024-03-20

造血干细胞表观遗传学

组蛋白变体

Histone variants contribute to the complexity of the chromatin landscape and play an integral role in defining DNA domains and regulating gene expression. The histone H3 variant H3.3 is incorporated i

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Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia

白血病发病机制

造血干细胞表观遗传学

RUNX1 is among the most frequently mutated genes in human leukemia, and the loss or dominant-negative suppression of RUNX1 function is found in myelodysplastic syndrome and acute myeloid leukemia (AML

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Distinct functions of wild-type and mutant ?133p53a R273H differentially regulate glioblastoma aggressiveness and therapy-induced senescence

p53突变功能研究

胶质母细胞瘤治疗反应

Mutations effects on p53 isoforms' activities remain largely unknown, although they are mutated in 92% of TP53 mutant cancers. Therefore, exploring the effect of mutations on p53 isoforms activities i

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DNA methylation profiles of freshly isolated CD34+ cells and upon expansion on either tissue culture plastic (TCP) or mesenchymal stromal cells (MSCs)

造血干细胞表观遗传学

体外培养模型评估

Hematopoietic stem and progenitor cells (HPCs) can be maintained in vitro, but the vast majority of their progeny loses “stemness” during culture. In this study, we have analyzed DNA methylation (DNAm

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Mutant p53 knockdown efficiency of T4 using different amount of cells.

基因敲低效率评估

p53突变功能研究

Mutant p53 knockdown efficiency of T4 using different amount of cells.

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