Supplementary data: Cost of hepatic decompensation and liver transplantation events in primary biliary cholangitis: a retrospective observational study

These are peer-reviewed supplementary materials for the article 'Cost of hepatic decompensation and liver transplantation events in primary biliary cholangitis: a retrospective observational study' published in the Journal of Comparative Effectiveness Research.Supplemental Table 1: Hepatic decompensation-related diagnosis codes and descriptionsSupplemental Table 2: Hepatic decompensation-related procedure codes and descriptionsSupplemental Table 3: Health Care Provider Taxonomy codes for post-discharge and post-transplant specialist visitsSupplemental Table 4: Clinical evaluations, laboratory tests, procedures, treatments, and encounters included in the pre-transplant evaluationSupplemental Table 5: Current Procedural Terminology codes and descriptions for liver transplantation proceduresAim: Complications of primary biliary cholangitis (PBC) are proposed to confer substantial economic burden to patients and healthcare systems. This retrospective observational study evaluated the cost of PBC-related hepatic decompensation and liver transplantation using a large administrative claims database. Materials & methods: Patients aged ≥18 years at the time of first claim with a diagnosis of PBC were identified using Optum’s de-identified Clinformatics R ? Data Mart Database. Two cohorts were established based on the type of event (hepatic decompensation or liver transplantation) that patients experienced on or after the date of their first claim with the PBC diagnosis. Costs for the hepaticdecompensation hospitalization and 30-day post-discharge period were examined at the event level. Hospitalizations occurring within the 30-day post-discharge period after a hepatic decompensation event were considered readmissions, and costs from the initial event were combinedwith those from the ensuing readmissions. In the liver transplantation cohort, costs for the pretransplant evaluation, hospitalization for transplantation, and post-transplant care and complications were assessed per patient. Results: A total of 2118 and 163 patients met study inclusion criteria in the hepatic decompensation and liver transplantation cohorts, respectively. The overall mean cost per hepatic decompensation event (n = 3581) was $63,612.09. The mean cost per event with readmission within 30 days (n = 991, 27.7%) was $116,424.25; for events without readmission, the mean cost was $43,404.81. The mean total cost of liver transplantation per patient was $328,336.60. Themean cost per patient was highest for the hospitalization for transplantation ($226,908.70). Conclusion: This comprehensive cost analysis demonstrates the high-cost burden of PBC disease progression. Appropriate patient management may help to mitigate the economic burden of PBC-related hepatic decompensation and liver transplantation.