A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis

We present here liver lipidomic data from
eight-week old male C57BL/6N wild-type mice receving normal chow diet (NCD),
high-fat diet (HFD) or a combination of high-fat diet treated with the S6K1
inhibitor LY2584702 tosylate (HFD+LY) during 10 weeks (4 animals/experimental
condition). The analysis of lipids was performed by direct flow
injection analysis (FIA) using either a triple quadrupole mass spectrometer
(FIA-MS/MS; QQQ triple quadrupole) or a hybrid quadrupole-Orbitrap mass
spectrometer (FIA-FTMS; high mass resolution). FIA-MS/MS (QQQ) was performed in
positive ion mode using the analytical setup and strategy described previously (Höring et al.,2021; Höring et al., 2020; Höring et al., 2019)