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The Cohesin Complex Cooperates with Pluripotency Transcription Factors in the Maintenance of Embryonic Stem Cell Identity

ChEBI2011-05-19 更新2026-07-21 收录

胚胎干细胞多能性调控

黏连蛋白复合体功能

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-24030 数据链接链接失效反馈

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资源简介：

The Cohesin Complex Cooperates with Pluripotency Transcription Factors in the Maintenance of Embryonic Stem Cell Identity

应用场景：

创建时间：

2011-05-19

胚胎干细胞多能性调控

DNA Methylation

Mouse embryonic stem cells (mESCs) can convert to a ground state by dual inhibition of MEK and GSK3β signalling in defined media in the presence of LIF (2i). The cellular transition in 2i leads to uni

NIAID Data Ecosystem110

Characterization of the Interaction between the Cohesin Subunits Rad21 and SA1/2

黏连蛋白复合体功能

染色体分离机制

The cohesin complex is responsible for the fidelity of chromosomal segregation during mitosis. It consists of four core subunits, namely Rad21/Mcd1/Scc1, Smc1, Smc3, and one of the yeast Scc3 ortholog

NIAID Data Ecosystem70

Histone Deacetylases (HDACs) are essential for transcription of the pluripotent network in embryonic stem cells [Pro-Seq]. Histone Deacetylases (HDACs) are essential for transcription of the pluripotent network in embryonic stem cells [Pro-Seq]

胚胎干细胞多能性调控

表观遗传转录机制

Histone acetylation is a dynamic modification regulated by the opposing actions of histone acetyltransferases and histone deacetylases (HDACs). Deacetylation of histone tails results in chromatin tigh

NIAID Data Ecosystem60

BACH1 Recruits NANOG and Histone H3 Lysine 4 Methyltransferase MLL/SET1 Complexes to Regulate Enhancer-promoter Activity and Maintains Pluripotency

胚胎干细胞多能性调控

增强子-启动子互作

Maintenance of stem-cell identity requires proper regulation of enhancer activity. Both transcription factors OCT4/SOX2/NANOG and histone methyltransferase complexes MLL/SET1 were shown to regulate en

NIAID Data Ecosystem80

Expression regulation by Phc1 in mouse embryonic stem cells

胚胎干细胞多能性调控

Polycomb功能

Polycomb group (PcG) proteins maintain cell identity by transcriptionally silencing developmental genes during embryogenesis. Phc1 is a subunit of cPRC1 known for gene repression, in the maintenance o

NIAID Data Ecosystem60

The Cohesin Complex Cooperates with Pluripotency Transcription Factors in the Maintenance of Embryonic Stem Cell Identity

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