Identification of the molecular signature of distinctive breast cancer associated fibroblasts (CAFs)

Cancer associated fibroblasts (CAFs) are highly heterogeneous and different subsets of CAFs may exhibit distinct functions, To identify the molecular signature of distinctive CAFs , we compared mRNA expression profiles of CAFs isolated from tumors in sensitive patients and resistant ones before neo-adjuvant chemotherapy. Compared the CAFs from sensitive samples, those from refractory samples exhibited a distinctive signature. A fourteen chip study using total RNA recovered from CAFs of 7 sensitive breast cancer patients and 7 resistant ones before neo-adjuvant chemotherapy. Each chip measures the expression 45033 genes were collected from the authoritative data source including NCBI.