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2021-03-25
相关数据集
Extraction of human DNA replication timing patterns from discrete microarray data
Effective reproduction is essential for the survival and proliferation of any organism, from the birth of new offspring to the repro- duction of individual cells. Each portion of a cell’s DNA must be
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Spearman rank pair-wise correlation coefficients between the 7 subtypes and Luminal-like.
The highest correlation between Luminal-like and any of the other subtypes is marked in Bold. The correlation of a centroid to itself is marked in Italics.
NIAID Data Ecosystem30
Cohesin maintains replication timing to suppress DNA damage on cancer genes [PEM-seq]. Cohesin maintains replication timing to suppress DNA damage on cancer genes [PEM-seq]
Cohesin loss-of-function mutations are frequently observed in tumors, but the mechanism is unclear. Here, we found that depletion of RAD21, a core subunit of cohesin, leads to massive genome-wide DNA
NIAID Data Ecosystem20
Profiling replication timing in WT, MLL3KO and MLL3/4dKO cells during naive to formative ESC differentiation [Bio-Repli-seq]. Profiling replication timing in WT, MLL3KO and MLL3/4dKO cells during naive to formative ESC differentiation [Bio-Repli-seq]
We performed BioRepli-seq for WT, MLL3KO and MLL3/4dKO ESCs the naive to formative ESC differentiation. Overall design: Three replicates derived from independent cultures were collected per genotype a
NIAID Data Ecosystem30
Germline DNA replication timing shapes mammalian genome composition. Germline DNA replication timing shapes mammalian genome composition
DNA Replication Timing (RT) has been suggested to play an important role in shaping the mammalian genome by affecting mutation rates. Previous analyses were limited in that they relied on somatic DNA
NIAID Data Ecosystem30
