Crystal structure of glycogen phophorylase complexed with an anthranilimide based inhibitor GSK254
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Crystal structure of glycogen phophorylase complexed with an anthranilimide based inhibitor GSK254 Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-cyclohexyl-N-[(3-{[(2,4,6-trimethylphenyl)carbamoyl]amino}naphthalen-2-yl)carbonyl]-D-alanine, ... Authors: Nolte, R.T. Deposit date: 2008-06-04 Release date: 2009-04-21 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.57 Å) Cite: Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy. Bioorg.Med.Chem.Lett., 19, 2009
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2008-06-04
