Exocytosis of ficolin-rich granule membrane proteins

Ficoli-1 rich granules are a relatively new fourth neutrophil granule population that is enriched in the microbial lectin ficolin-1. Ficolin-1 is present in tertiary granules, but ficolin-1 rich granules can be differentiated by having low levels of gelatinases and an elevated exocytosis propensity (Rorvig et al. 2009, 2013). The importance of these granules may be to provide rapid release of pattern recognition molecules to activate the lectin complement pathway (Rorvig et al. 2009).

Ficoli-1富集颗粒是一种相对较新的第四类中性粒细胞颗粒群，其中富含微生物凝集素ficolin-1。ficolin-1存在于三级颗粒中，但富集ficolin-1的颗粒可通过低水平的明胶酶活性和增强的胞吐倾向来区分（Rorvig等，2009，2013）。这些颗粒的重要性可能在于提供快速释放模式识别分子，以激活凝集素补体途径（Rorvig等，2009）。