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TAF1 is critical for AE driven leukemogenesis [ChIP-seq]

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NIAID Data Ecosystem2026-03-11 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115115
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资源简介:
TAF1 is essential for AE driven leukemogenesis. Depletion of TAF1 impairs the recruitment of AE to its target genes, interfering with its control of gene expression. The bromodomains of TAF1 associate with K43 acetylated AE and this association plays a role in the proliferation of AE expressing AML cells. ChIP was performed on Kasumi-1 cells with antibodies targeting ETO, TAF1, H3K27ac, or H3K4me1.
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2019-11-04
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