Differences in inflammatory profile in PTB patients of African vs. Eurasian ancestry.

A: age, sex, duration of symptoms pre-diagnosis, duration of antimicrobial therapy pre-sampling, baseline serum 25-hydroxyvitamin D concentration; B: MTB genotype categorised as Indo-Oceanic, East Asian, East African-Indian, Euro-American and West African strain lineage. C: host DBP genotype categorised as Gc1F/1F, 1F/2, 2/2, 1F/1S, 2/1S and 1S/1S as per ref [21]. D: age, sex, duration of symptoms pre-diagnosis, duration of antimicrobial therapy pre-sampling, isolate sensitive vs. resistant to isoniazid, allocation to vitamin D vs. placebo. E. t-statistic (regression co-efficient/standard deviation ) represents magnitude of difference between ethnic groups; a negative t-statistic indicates a lower concentration of immunological parameter in participants of African vs. Eurasian ancestry, and vice versa. F, p values derived using the t-test for general linear models, with adjustment for covariates (A–D). Parameters with a false discovery rate (q-value)>0.05, determined by the Benjamini Hochberg approach, were designated non-significant (ns). For the purposes of applying this approach, each ‘family’ of hypotheses corresponded to a single column of presented p values for either circulating or antigen-stimulated samples. G, stimulated with recombinant culture filtrate protein, 10 kDa (rCFP-10).
MTB, Mycobacterium tuberculosis; CCL, CC chemokine ligand; CXCL, CXC chemokine ligand; DBP, vitamin D binding protein; IL, interleukin; RA, receptor antagonist; HGF, hepatocyte growth factor.