We comprehensively interrogate enhancers U1 and U2 in controlling Nkx2-5 transcription during heart development. Serial genomic deletions in mice reveal a functional hierarchy of U1 and U2 as evidence

NIAID Data Ecosystem40

Competition for H2A.Z underlies the developmental impacts of repetitive element de-repression

发育表观遗传学

染色质调控

The histone variant H2A.Z is central to early embryonic development, determining transcriptional competency through chromatin regulation of gene promoters and enhancers. In addition to genic loci, we

NIAID Data Ecosystem40

Genome-wide epigenetic reprogramming during chick embryonic development. Genome-wide epigenetic reprogramming during chick embryonic development

发育表观遗传学

染色质修饰动态

In mice, genome-wide DNA methylation is actively erased at the onset of fertilisation, followed by remethylation in epiblasts after implantation, leading to inactive chromatin formation as a prelimina

NIAID Data Ecosystem60

Genome-Wide Dynamics of Replication Timing Revealed by In Vitro Models of Mouse Embryogenesis (Expression)

发育表观遗传学

时序控制

Differentiation of mouse embryonic stem cells (mESCs) is accompanied by changes in replication timing. To explore the relationship between replication timing and cell fate transitions, we constructed

NIAID Data Ecosystem40

Epigenetically heritable alteration of fly development in response to toxic challenge

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