Transciptome profile of liver tissues from CD163KO mice after 8 weeks of Western diet.

Liver macrophages have a high expression of the macrophage-specific scavenger receptor CD163 but during metabolic dysfunction-associated steatohepatitis (MASH) development CD163 undergoes increased shedding and downregulated expression in the liver in humans. Herein, we derived a hepatic-transcriptome based dataset to understand the development of early hepatic steatosis in CD163 knockout mice and their littermate controls. RNA-seq profiling of liver tissue obtained from C57BL/6NTac (CD163tm1(KOMP)Vlcg) mice after 8 weeks of chow (n=4-5 per genotype) or Western diet (n=15 pr. genotype).