TNFepitope: A Webserver for Prediction of TNF-α Inducing Epitopes

TNFepitope: A Webserver for Prediction of TNF-α Inducing Epitopes TNFepitope is a host-specific computational tool developed for the prediction, design, and scanning of Tumor Necrosis Factor-alpha (TNF-α) inducing epitopes. TNF-α is a major pro-inflammatory cytokine involved in immune regulation, inflammation, cancer, autoimmune disorders, viral infections, and cytokine release syndrome. TNFepitope helps researchers identify peptide regions that may induce TNF-α production, supporting peptide-based vaccine design, subunit vaccine development, and immunotherapy research. Web Server TNFepitope Web Server:https://webs.iiitd.edu.in/raghava/tnfepitope/ Citation If you use TNFepitope in your research, please cite: Dhall, A., Patiyal, S., Choudhury, S., Jain, S., Narang, K., and Raghava, G.P.S. TNFepitope: A webserver for the prediction of TNF-α inducing epitopes. Computers in Biology and Medicine, 160, 106929, 2023. DOI: https://doi.org/10.1016/j.compbiomed.2023.106929 About TNFepitope Tumor Necrosis Factor-alpha, also known as TNF-α, is a pleiotropic pro-inflammatory cytokine that plays an important role in: Immune signaling Inflammatory response Viral infection response Cancer biology Autoimmune disorders Cytokine release syndrome Higher TNF-α expression has been associated with several diseases, including cancer, autoimmune disorders, rheumatoid arthritis, diabetes, Crohn’s disease, inflammatory bowel disease, HIV infection, and COVID-19-related cytokine storm. TNFepitope was developed to identify peptide epitopes that can induce TNF-α production. These epitopes can be useful for understanding inflammatory immune responses and designing peptide-based immunotherapeutic strategies.