Protection against development of diabetes in female SR-A−/− NOD mice.

(A)Blood glucose was monitored weekly in each of 10 mice starting when mice reached 4 weeks old and continuing up to 40 weeks of age. Glucose levels >250 mg/dl for 2 consecutive days were defined as diabetes. The development of diabetes was significantly suppressed in female SR-A−/− NOD mice (* p value = 0.0261, compared with littermates, log-rank test). Representative histological appearances are shown for SR-A−/− NOD mice and NOD mice, (B) at 8 weeks of age, and (C) at 13 weeks of age.