Enzyme-like nanoparticle engineered-mesenchymal stem cell secreting HGF promotes visualized therapy for idiopathic pulmonary fibrosis in vivo

Stem cell therapy has emerged as a potential alternative treatment for idiopathic pulmonary fibrosis (IPF). However, its efficacy remains challenging due to factors such as ROS and inflammation in fibrotic lungs. Moreover, the distribution, migration, and survival of transplanted stem cells are still unclear, significantly impeding the clinical advancement of stem cell therapy. To tackle these challenges, we fabricate trimetallic-based nanocarriers (TBNCs) with enzyme-like activity and plasmid loading capabilities, aiming to efficiently eradicate ROS and facilitate delivery therapeutic genes and ultimately improve the therapeutic efficacy. Simultaneously, TBNCs function as an excellent CT contrast agent for tracking mesenchymal stem cells (MSCs), can improve the therapy by visualization-guiding. TBNCs was co-incubated with a hepatocyte growth factor plasmid gene to create TBNCs@pDNA, and then MSCs were modified with TBNCs@pDNA through endocytosis to generate engineered-MSCs, which demon..., , , # Enzyme-like nanoparticle-engineered mesenchymal stem cell secreting HGF promotes visualized therapy for idiopathic pulmonary fibrosis in vivo

[https://doi.org/10.5061/dryad.gmsbcc2wt](https://doi.org/10.5061/dryad.gmsbcc2wt) 

This dataset includes, all additional raw experimental data are presented in the main and supplementary figures of the manuscript.

Summary of dataset contents:

Three key datasets are included to provide all the data utilized in the manuscript supporting the conclusion that the enzyme-like nanoparticle-engineered mesenchymal stem cell secreting HGF promotes visualized therapy for idiopathic pulmonary fibrosis in vivo. The first and second datasets contain all the original data from the main manuscript (Raw data for main figures) and the supplemental materials (Raw data for supplemental figures), respectively. Initially, the successful synthesis of TBNCs was demonstrated by various characterization methods. Subsequently, the functional regulation and therapeuti...