Molecular roadmap of the healthy stress response in the mouse hippocampus (small RNA). Molecular roadmap of the healthy stress response in the mouse hippocampus (small RNA)

The acute stress response mobilizes energy to meet situational demands and re-establish homeostasis. Here, we used a brief forced swim exposure to trigger a strong stress response in mice. Using multiomic profiling we characterize the stress-induced molecular events in the dorsal (dHC) and ventral (vHC) hippocampus over time, across molecular scales, and down to the level of cell types and single cells. Overall design: Here, we used a brief (6min) forced swim exposure and profiled the hippocampus using small RNA sequencing 45min after initiation of the experiment.