Deep immunophenotyping reveals circulating activated lymphocytes in individuals at-risk for rheumatoid arthritis

Using data from the AMP RA.SLE Phase II PBMC CITE-seq and AMP RA.SLE PhaseII CyTOF datasets, investigators examined PBMC gene and protein expression patterns and systematically identified activated lymphocyte phenotypes in RA At-Risk individuals, along with immunophenotypic differences between different At-Risk subpopulations